Although antidepressants and antipsychotics are commonly prescribed for children and adolescents, their side effects have been largely unexplored in pediatrics. In adults, however, antidepressants have been found to cause lower bone mineral density (BMD) and an increased risk for fractures, while antipsychotics have been associated with weight gain and changes in body composition, leading to metabolic syndrome.

Because of its generally mild symptoms and physical signs, the genetic condition Klinefelter Syndrome (KS) continues to be underdiagnosed, explained Ilene Fennoy, MD, MPH, Professor of Pediatrics, NewYork-Presbyterian/Morgan Stanley Children’s Hospital at Columbia University Medical Center.